NTNG1 - netrin G1 Gene

Also Known as Lmnt1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 22854

About NTNG1

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:107,140,088-107,484,923 (from NCBI)

This gene has 10 transcripts (splice variants), 270 orthologues, 27 paralogues and is associated with 2 phenotypes. Broad expression in brain (RPKM 1.0), kidney (RPKM 0.9) and 14 other tissues.

Summary

This gene encodes a preproprotein that is processed into a secreted protein containing eukaroytic growth factor (EGF)-like domains. This protein acts to guide axon growth during neuronal development. Polymorphisms in this gene may be associated with Schizophrenia. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2015]

NTNG1 Products (11)

mRNA Protein Name
NM_001113226.3 NP_001106697.1 netrin-G1 isoform G1a preproprotein
NM_001113228.3 NP_001106699.1 netrin-G1 isoform G1d precursor
NM_001312688.2 NP_001299617.1 netrin-G1 isoform G1n precursor
NM_001330665.2 NP_001317594.1 netrin-G1 isoform 5 precursor
NM_001372166.1 NP_001359095.1 netrin-G1 isoform 6 precursor
NM_001372167.1 NP_001359096.1 netrin-G1 isoform G1a preproprotein
NM_001372168.1 NP_001359097.1 netrin-G1 isoform G1c precursor
NM_001372169.1 NP_001359098.1 netrin-G1 isoform G1d precursor
NM_001372170.1 NP_001359099.1 netrin-G1 isoform G1a preproprotein
NM_001372171.1 NP_001359100.1 netrin-G1 isoform G1c precursor
NM_014917.4 NP_055732.2 netrin-G1 isoform G1c precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables cell adhesion molecule binding IPI
IPI: Inferred from physical interaction
23986473 GOA
enables cell-cell adhesion mediator activity IGI
IGI: Inferred from genetic interaction
23986473 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
14595443 GOA
Biological Process GO Annotation Evidence References Source
involved in synaptic membrane adhesion IGI
IGI: Inferred from genetic interaction
23986473 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NTNG1 Protein Structure

Laminin_N

Laminin_N: Laminin N-terminal (Domain VI) (69 - 295)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (297 - 341)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (364 - 417)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (420 - 457)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 539 a.a.
Protein Preferred Names Protein Names

netrin-G1

  • axon guidance molecule

NTNG1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NTNG1 Q9Y2I2 NUDT16L1 Homo sapiens Q9BRJ7
Anti Tag CoIP
33961781
Intra
NTNG1 Q9Y2I2 LRRC4C Homo sapiens Q9HCJ2
X-Ray Diffraction
21946559
Intra
NTNG1 Q9Y2I2 LRRC4C Homo sapiens Q9HCJ2
Light Scattering
21946559
Intra
NTNG1 Q9Y2I2 LRRC4 Homo sapiens Q9HBW1
SPR
21946559
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NTNG1 Proteins

Cat. No. Product Name Accession Purity
HY-P71175 NTNG1 Protein, Human (Biotinylated, HEK293, Avi-His) Q9Y2I2-1 (H29-S409) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P71176 NTNG1 Protein, Human (HEK293, His) Q9Y2I2-1(H29-S409) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Rett Syndrome

  • Atypical Rett Syndrome

  • RTT

  • Rett Disorder

  • Rts

  • Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use

  • Rett Syndrome, Preserved Speech Variant

  • Rett Syndrome, Atypical

  • Rett'S Disorder

  • Rett Syndrome Variant

  • Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome

  • Cerebroatrophic Hyperammonemia

  • Rett Like Syndrome

  • Rett'S Syndrome

  • Atypical Rtt

  • Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use

  • Rett Syndrome Preserved Speech Variant

  • Rett Syndrome Zappella Variant

  • Rett Syndrome, Zappella Variant
Non-Specific Syndromic Intellectual Disability

  • Complex Neurodevelopmental Disorder
Schizophrenia 12

  • Sczd12

  • Schizophrenia Susceptibility Locus, Chromosome 1p-Related
Partial Fetal Alcohol Syndrome
St. Louis Encephalitis

  • Saint Louis Encephalitis

  • Neuroinvasive St. Louis Encephalitis Virus Infection

  • Encephalitis, St. Louis

  • Neuroinvasive Saint Louis Encephalitis Virus Infection

  • St. Louis Encephalitis Virus Infection

  • St. Louis Encephalitis Virus Neuroinvasive Disease

  • St. Louis Viral Disease

  • Type C Lethargic Encephalitis

  • Encephalitis Type C
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Intellectual Developmental Disorder, Autosomal Dominant 41

  • MRD41

  • Autosomal Dominant Non-Syndromic Intellectual Disability 41

  • Mental Retardation, Autosomal Dominant 41

  • Autosomal Dominant Intellectual Developmental Disorder 41

  • Autosomal Dominant Mental Retardation 41

  • Mental Retardation, Autosomal Dominant, Type 41
Glass Syndrome

  • Chromosome 2q32-Q33 Deletion Syndrome

  • Satb2-Associated Syndrome

  • 2q33.1 Microdeletion Syndrome

  • Sas

  • 2q32-Q33 Microdeletion Syndrome

  • 2q32q33 Microdeletion Syndrome

  • Monosomy 2q32

  • Monosomy 2q32-Q33

  • Monosomy 2q32q33

  • 2q32 Deletion Syndrome

  • Del(2)(Q32)

  • Del(2)(Q32q33)

  • GLASS

  • 2q32q33 Microdeletion Syndromes

  • Satb2 Syndrome

  • Satb2-Associated Syndrome Due To A Chromosomal Rearrangement

  • Del(2)(Q33.1)

  • Monosomy 2q33.1

  • Satb2-Associated Syndrome Due To A Pathogenic Variant

  • Satb2-Associated Syndrome Due To A Point Mutation

  • Satb2 Associated Disorder
Alcohol-Related Birth Defects

  • Arbd

  • Alcohol-Related Birth Defect

  • Alcohol Related Birth Defect

  • Fetal Alcohol Syndrome
Ventricular Tachycardia, Catecholaminergic Polymorphic, 1, With Or Without Atrial Dysfunction And/Or Dilated Cardiomyopathy

  • Catecholaminergic Polymorphic Ventricular Tachycardia 1

  • Ventricular Tachycardia, Catecholaminergic Polymorphic, 1

  • CPVT1

  • Ventricular Tachycardia, Stress-Induced Polymorphic

  • Vtsip

  • Bidirectional Tachycardia

  • Stress-Induced Polymorphic Ventricular Tachycardia

  • Cvpt1

  • Double Tachycardia Induced By Catecholamines

  • Malignant Paroxysmal Ventricular Tachycardia

  • Multifocal Ventricular Premature Beats

  • Paroxysmal Ventricular Fibrillation

  • Syncopal Paroxysmal Tachycardia

  • Syncopal Tachyarythmia

  • Ventricular Tachycardia Catecholaminergic Polymorphic 1

  • Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 1

  • Multifocal Pvcs

  • Multifocal Premature Ventricular Beats

  • Paroxysmal Familial Ventricular Fibrillation

  • Catecholaminergic Polymorphic Ventricular Tachycardia Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS20458 Ntng1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09625 NTNG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09626 NTNG2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26967 Ntng1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NTNG1 VGNC VGNC:50086
Canis familiaris NTNG1 VGNC VGNC:58321
Felis catus NTNG1 VGNC VGNC:63906
Rattus norvegicus NTNG1 RGD RGD:1563465
Mus musculus NTNG1 MGD MGI:1934028
Macaca mulatta NTNG1 VGNC VGNC:75450
Others NTNG1 NCBI