ARHGAP35 - Rho GTPase activating protein 35 Gene

Also Known as GRF-1; GRLF1; P190A; P190-A; p190RhoGAP; p190ARhoGAP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2909

About ARHGAP35

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:46,860,997-47,005,077 (from NCBI)

This gene has 6 transcripts (splice variants), 200 orthologues, 4 paralogues and is associated with 83 phenotypes. Broad expression in testis (RPKM 28.9), brain (RPKM 18.7) and 25 other tissues.

Summary

The human Glucocorticoid Receptor DNA binding factor, which associates with the promoter region of the Glucocorticoid Receptor gene (hGR gene), is a repressor of Glucocorticoid Receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids. [provided by RefSeq, Jul 2008]

ARHGAP35 Products (1)

mRNA Protein Name
NM_004491.5 NP_004482.4 rho GTPase-activating protein 35

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables GTPase activator activity IDA
IDA: Inferred from direct assay
19673492 GOA
enables phospholipid binding IDA
IDA: Inferred from direct assay
19673492 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGAP35 Protein Structure

Ras

Ras: Ras family (172 - 247)

FF

FF: FF domain (487 - 547)

RhoGAP

RhoGAP: RhoGAP domain (1262 - 1410)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1499 a.a.
Protein Preferred Names Protein Names

rho GTPase-activating protein 35

  • glucocorticoid receptor DNA-binding factor 1

ARHGAP35 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811175 Phospho-GRLF1 (Tyr1105) Antibody WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Uterine Corpus Endometrial Carcinoma
Frontotemporal Dementia

  • Pallidopontonigral Degeneration

  • Frontotemporal Lobar Degeneration

  • Semantic Dementia

  • FTD

  • Frontotemporal Lobe Dementia

  • Multiple System Tauopathy With Presenile Dementia

  • Dementia, Frontotemporal

  • Frontotemporal Dementia With Parkinsonism

  • Mstd

  • Frontotemporal Lobar Degeneration With Tau Inclusions

  • Ftld With Tau Inclusions

  • Dementia, Frontotemporal, With Parkinsonism

  • Fldem

  • Ftdp17

  • Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex

  • Ddpac

  • Wilhelmsen-Lynch Disease

  • Wld

  • Ppnd

  • Dementia, Frontotemporal, With Or Without Parkinsonism

  • Semantic Primary Progressive Aphasia

  • Semantic Variant Ppa

  • Wilhemsen-Lynch Disease

  • Frontotemporal Dementia-Amyotrophic Lateral Sclerosis

  • Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17

  • Ftd-Als

  • Ftld

  • Pick Complex

  • Pick Disease Of The Brain

  • Frontotemporal Dementia With Parkinsonism-17

  • Grn-Related Frontotemporal Dementia

  • Frontotemporal Dementia With Motor Neuron Disease

  • Dementia In Fronto-Temporal Lobar Degeneration

  • Ftd - [Frontotemporal Dementia]

  • Temple Dementia

  • Frontal Lobe Dementia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00933 ARHGAP35 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ARHGAP35 VGNC VGNC:26092
Canis familiaris ARHGAP35 VGNC VGNC:38060
Mus musculus ARHGAP35 MGD MGI:1929494
Rattus norvegicus ARHGAP35 RGD RGD:1308738
Felis catus ARHGAP35 VGNC VGNC:67475
Macaca mulatta ARHGAP35 VGNC VGNC:69942
Others ARHGAP35 NCBI