ARHGAP35 - Rho GTPase activating protein 35 Gene

Homo sapiens

Also known as GRF-1; GRLF1; P190A; P190-A; p190RhoGAP; p190ARhoGAP

Gene ID: 2909 | Gene type: protein coding

About ARHGAP35

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:46,860,997-47,005,077 (from NCBI)

This gene has 6 transcripts (splice variants), 200 orthologues, 4 paralogues and is associated with 83 phenotypes. Broad expression in testis (RPKM 28.9), brain (RPKM 18.7) and 25 other tissues.

Summary

The human Glucocorticoid Receptor DNA binding factor, which associates with the promoter region of the Glucocorticoid Receptor gene (hGR gene), is a repressor of Glucocorticoid Receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids. [provided by RefSeq, Jul 2008]

ARHGAP35 Products(1)

mRNA	Protein	Name
NM_004491.5	NP_004482.4	rho GTPase-activating protein 35

ARHGAP35 Protein Structure

Ras

RhoGAP

0
300
600
900
1200
1499 a.a.

Protein Preferred Names

Protein Names

rho GTPase-activating protein 35

glucocorticoid receptor DNA-binding factor 1

Related Diseases

Diseases

Alias

Uterine Corpus Endometrial Carcinoma

Frontotemporal Dementia

Pallidopontonigral Degeneration	Frontotemporal Lobar Degeneration
Semantic Dementia	FTD
Frontotemporal Lobe Dementia	Multiple System Tauopathy With Presenile Dementia
Dementia, Frontotemporal	Frontotemporal Dementia With Parkinsonism
Mstd	Frontotemporal Lobar Degeneration With Tau Inclusions
Ftld With Tau Inclusions	Dementia, Frontotemporal, With Parkinsonism
Fldem	Ftdp17
Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex	Ddpac
Wilhelmsen-Lynch Disease	Wld
Ppnd	Dementia, Frontotemporal, With Or Without Parkinsonism
Semantic Primary Progressive Aphasia	Semantic Variant Ppa
Wilhemsen-Lynch Disease	Frontotemporal Dementia-Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17	Ftd-Als
Ftld	Pick Complex
Pick Disease Of The Brain	Frontotemporal Dementia With Parkinsonism-17
Grn-Related Frontotemporal Dementia	Frontotemporal Dementia With Motor Neuron Disease
Dementia In Fronto-Temporal Lobar Degeneration	Ftd - [Frontotemporal Dementia]
Temple Dementia	Frontal Lobe Dementia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00933	ARHGAP35 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ARHGAP35	VGNC	VGNC:26092
Canis familiaris	ARHGAP35	VGNC	VGNC:38060
Mus musculus	ARHGAP35	MGD	MGI:1929494
Rattus norvegicus	ARHGAP35	RGD	RGD:1308738
Felis catus	ARHGAP35	VGNC	VGNC:67475
Macaca mulatta	ARHGAP35	VGNC	VGNC:69942

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