HBQ1 - hemoglobin subunit theta 1 Gene

Also Known as HBQ

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3049

About HBQ1

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:180,459-181,179 (from NCBI)

This gene has 1 transcript (splice variant), 79 orthologues and 11 paralogues.

Summary

Theta-globin mRNA is found in human fetal erythroid tissue but not in adult erythroid or Other nonerythroid tissue. The theta-1 gene may be expressed very early in embryonic life, perhaps sometime before 5 weeks. Theta-1 is a member of the human alpha-globin gene cluster that involves five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-2 -pseudoalpha-1 - alpha-2 - alpha-1 - theta-1 - 3'. Research supports a transcriptionally active role for the gene and a functional role for the peptide in specific cells, possibly those of early erythroid tissue. [provided by RefSeq, Jul 2008]

HBQ1 Products (1)

mRNA	Protein	Name
NM_005331.5	NP_005322.1	hemoglobin subunit theta-1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HBQ1 Protein Structure

Globin

0
100
142 a.a.

Protein Preferred Names	Protein Names
hemoglobin subunit theta-1	hemoglobin theta-1 chain

HBQ1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HBQ1	P09105	RFESD	Homo sapiens	Q8TAC1	Y2H Array	31515488
Intra	HBQ1	P09105	RFESD	Homo sapiens	Q8TAC1	Y2H Prey Pooling	25416956
Intra	HBQ1	P09105	RFESD	Homo sapiens	Q8TAC1	Y2H Array	25416956
Intra	HBQ1	P09105	RFESD	Homo sapiens	Q8TAC1	Validated Y2H	25416956
Intra	HBQ1	P09105	RFESD	Homo sapiens	Q8TAC1	Validated Y2H	32296183
Intra	HBQ1	P09105	HBG2	Homo sapiens	P69892	Validated Y2H	32296183
Intra	HBQ1	P09105	HBD	Homo sapiens	P02042	Validated Y2H	25416956
Intra	HBQ1	P09105	HBD	Homo sapiens	P02042	Y2H Array	25416956
Intra	HBQ1	P09105	HBA1	Homo sapiens	P69905	Validated Y2H	32296183
Intra	HBQ1	P09105	HBA1	Homo sapiens	P69905	Y2H Prey Pooling	32296183
Intra	HBQ1	P09105	HBA1	Homo sapiens	P69905	Y2H Array	32296183
Intra	HBQ1	P09105	HBB	Homo sapiens	P68871	Validated Y2H	32296183
Intra	HBQ1	P09105	HBB	Homo sapiens	P68871	Y2H Prey Pooling	32296183
Intra	HBQ1	P09105	HBB	Homo sapiens	P68871	Y2H Array	32296183
Intra	HBQ1	P09105	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HBQ1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70272	Hemoglobin subunit theta-1/HBQ1 Protein, Human (His)	P09105 (M1-R142)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Hemoglobin E Disease	Hemoglobin E Hb-E Disease
Thalassemia	Sickle-Cell Thalassemia With Crisis Sickle-Cell Thalassemia Without Crisis Thalassemia Hb-S Disease With Crisis Thalassemia Hb-S Disease Without Crisis Thalassemias Hereditary Leptocytosis Haemoglobin Thalassaemia Disorder Thalassaemia Syndrome Thalassaemia Nos Thalassemia Variants
Histiocytosis-Lymphadenopathy Plus Syndrome	H Syndrome Histiocytosis With Joint Contractures And Sensorineural Deafness Faisalabad Histiocytosis Shml Hjcd Rosai-Dorfman Disease Pigmented Hypertrichosis With Insulin-Dependent Diabetes Mellitus Phid Sinus Histiocytosis And Massive Lymphadenopathy Familial Rosai-Dorfman Disease Slc29a3 Spectrum Disorder Sinus Histiocytosis With Massive Lymphadenopathy Histiocytosis And Lymphadenopathy With Or Without Cutaneous, Cardiac, And/Or Endocrine Features, Joint Contractures, And/Or Deafness Hyperpigmentation, Cutaneous, With Hypertrichosis, Hepatosplenomegaly, Heart Anomalies, And Hypogonadism With Or Without Hearing Loss Rosai-Dorfman Disease, Familial Cutaneous Hyperpigmentation With Hypertrichosis, Hepatosplenomegaly, Heart Anomalies, And Hypogonadism With Or Without Hearing Loss Histiocytosis And Lymphadenopathy With Or Without Cutaneous, Cardiac, And/Or Endocrine Features, Joint Contractures And/Or Deafness Rdd Rosaï-Dorfman Disease Slc29a3 Disorder Destombes-Rosai-Dorfman Disease Rosai-Dorfman-Destombes Disease HLAS Cutaneous Hyperpigmentation With Hypertrichosis Hepatosplenomegaly Heart Anomalies And Hypogonadism With Or Without Hearing Loss Histiocytosis And Lymphadenopathy With Or Without Cutaneous Cardiac And/Or Endocrine Features Joint Contractures And/Or Deafness H Disease Sinus Histiocytosis
Hemoglobin H Disease	HBH Hemoglobin H Disease, Nondeletional Hemoglobin H Disease, Deletional Alpha-Thalassemia Intermedia Haemoglobin H Disease Alpha-Thalassemia, Hemoglobin H Type Hemoglobin H Disease, Deletional And Nondeletional Alpha Thalassemia, Haemoglobin H Type Alpha Thalassemia, Hemoglobin H Type Haemoglobin H Disease, Deletional Hbh Disease Alpha-Thalassemia Hemoglobin H Type Hemoglobin H Disease Deletional Hemoglobin H Disease Non-Deletional Alpha-Thalassemia Alpha - /- - Or Mutational Forms Of Alpha-Thalassaemia Alpha Thalassaemia Intermedia
Hemoglobin D Disease	Hb-D Disease Punjab Disease Los Angeles Disease Hb D Los Angeles Disease Hb D Punjab Disease
Fetal Hemoglobin Quantitative Trait Locus 1	Hereditary Persistence Of Fetal Hemoglobin Delta-Beta-Thalassemia Delta-Beta Thalassemia Delta Beta-Thalassemia HBFQTL1 Hemoglobin F, Hereditary Persistence Of Hpfh Hereditary Persistence Of Fetal Hemoglobin, Hb Gene Cluster-Related Hemoglobin, Fetal, Quantitative Trait Locus 1 Hereditary Persistence Of Fetal Hemoglobin Thalassemia Hpfh - [Hereditary Persistence Of Fetal Haemoglobin] Fetal Haemoglobin Persistence Of Fetal Haemoglobin Persistent Haemoglobin F
Heinz Body Anemias	Heinz Body Anemia Heinz Body Anemias, Alpha- HEIBAN Anemia, Heinz Body Acquired Heinz Body Anemia
Hemoglobinopathy	Hemoglobinopathies
Congenital Hemolytic Anemia	Anemia Hemolytic Congenital Anemia, Hemolytic, Congenital Congenital Hemolytic Anaemia Hereditary Hemolytic Anaemia Hereditary Hemolytic Anemia
Beta-Thalassemia Major	Cooley'S Anemia Cooley Anemia Mediterranean Anemia
Alpha-Thalassemia	Alpha Thalassemia Alpha Thalassaemia Alpha Plus Thalassemia Thalassemia, Alpha- Thalassemias, Alpha- A-Thalassemia Α-Thalassemia A-THAL Thalassemia Alpha Thalassaemia Syndrome
Hemoglobin C Disease	Hb C Disease Hemoglobin C Hb-C Disease
Alpha Thalassemia-Intellectual Disability Syndrome Type 1	Alpha Thalassemia-Intellectual Disability Syndrome, Deletion Type Alpha-Thalassemia-Intellectual Disability Syndrome Linked To Chromosome 16 Atr Syndrome Linked To Chromosome 16 Atr Syndrome, Deletion Type Atr-16 Syndrome Alpha Thalassemia-Retardation Syndrome Alpha-Thalassemia/Mental Retardation Syndrome, Deletion-Type Alpha-Thalassemia/Mental Retardation Syndrome, Type 1 Alpha-Thalassemia Mental Retardation Syndrome, Deletion-Type
Hemolytic Anemia	Anemia, Hemolytic Anemia Hemolytic Anaemia Due To Other Disorders Of Glutathione Metabolism Chronic Non Spherocytic Anaemia G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia Favism Anaemia Haemolytic Anaemia Due Tog6pd Deficiency Favism Pentose Phosphate Pathway Disorder Anaemia Anaemia Due To Pentose Phosphate Pathway Defect
Sickle Cell Anemia	Hemoglobin Sc Disease Anemia, Sickle Cell Hbsc Disease Sickle Cell-Hemoglobin C Disease Syndrome Hb Ss Disease Sickle Cell Trait Drepanocytosis Haemoglobin Sc Disease Hb Sc Disease Hb-S/Hb-C Disease Hb-Ss Disease Without Crisis Hemoglobin S Disease Without Crisis Sickle Cell Anaemia Sickle-Cell/Hb-C Disease Without Crisis Sickle Cell - Hemoglobin C Disease Hbs Disease Hemoglobin S Disease Sickling Disorder Due To Hemoglobin S SKCA Sickle Cell Disease Sickle Cell-Hemoglobin C Disease Sickle-Cell Disease Carrier Sickle-Cell Heterozygous Disorder Haemoglobin A-S Genotype Hb-S - [Sickle Cell Haemoglobin] Carrier Sickle Cell Haemoglobin Trait As - [Sickle Cell Trait] Hbas - [Sickle Cell Haemoglobin Trait] Sickle-Cell Trait Haemoglobin Disease Haemoglobin Sickle Cell Trait Disorder Heterozygous Sickle Cell Trait Hbas - [Heterozygous Haemoglobin S]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06034	HBQ1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25630	Hbq1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HBQ1	RGD	RGD:2320907
Others	HBQ1	NCBI