HBG2 - hemoglobin subunit gamma 2 Gene

Also Known as TNCY; HBG-T1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3048

About HBG2

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:5,253,188-5,254,781 (from NCBI)

This gene has 3 transcripts (splice variants), 549 orthologues, 11 paralogues and is associated with 5 phenotypes.

Summary

The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal Hemoglobin (HbF) which is normally replaced by adult Hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'- epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008]

HBG2 Products (1)

mRNA	Protein	Name
NM_000184.3	NP_000175.1	hemoglobin subunit gamma-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables oxygen carrier activity	IDA IDA: Inferred from direct assay	19065339	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in oxygen transport	IDA IDA: Inferred from direct assay	7543751	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of hemoglobin complex	IPI IPI: Inferred from physical interaction	881729	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HBG2 Protein Structure

Globin

0
100
147 a.a.

Protein Preferred Names	Protein Names
hemoglobin subunit gamma-2	G-gamma globin Paulinia

HBG2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HBG2	P69892	HBQ1	Homo sapiens	P09105	Y2H Prey Pooling	32296183
Intra	HBG2	P69892	HBQ1	Homo sapiens	P09105	Y2H Array	32296183
Intra	HBG2	P69892	XPNPEP1	Homo sapiens	Q9NQW7-3	Y2H Array	32296183
Intra	HBG2	P69892	XPNPEP1	Homo sapiens	Q9NQW7-3	Validated Y2H	32296183
Intra	HBG2	P69892	XPNPEP1	Homo sapiens	Q9NQW7-3	Y2H Prey Pooling	32296183
Intra	HBG2	P69892	HBM	Homo sapiens	Q6B0K9	Validated Y2H	32296183
Intra	HBG2	P69892	HBM	Homo sapiens	Q6B0K9	Y2H Prey Pooling	32296183
Intra	HBG2	P69892	HBM	Homo sapiens	Q6B0K9	Y2H Array	32296183
Intra	HBG2	P69892	HBA1	Homo sapiens	P69905	Y2H Prey Pooling	32296183
Intra	HBG2	P69892	HBA1	Homo sapiens	P69905	Validated Y2H	32296183
Intra	HBG2	P69892	HBA1	Homo sapiens	P69905	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cyanosis, Transient Neonatal	TNCY Cyanosis Transient Neonatal
Fetal Hemoglobin Quantitative Trait Locus 1	Hereditary Persistence Of Fetal Hemoglobin Delta-Beta-Thalassemia Delta-Beta Thalassemia Delta Beta-Thalassemia HBFQTL1 Hemoglobin F, Hereditary Persistence Of Hpfh Hereditary Persistence Of Fetal Hemoglobin, Hb Gene Cluster-Related Hemoglobin, Fetal, Quantitative Trait Locus 1 Hereditary Persistence Of Fetal Hemoglobin Thalassemia Hpfh - [Hereditary Persistence Of Fetal Haemoglobin] Fetal Haemoglobin Persistence Of Fetal Haemoglobin Persistent Haemoglobin F
Hemoglobinopathy Toms River	Transient Neonatal Cyanosis And Anemia Due To Toms River Hemoglobin
Hereditary Persistence Of Fetal Hemoglobin-Beta-Thalassemia Syndrome	Hpfh-Beta-Thalassemia Syndrome
Hereditary Persistence Of Fetal Hemoglobin-Sickle Cell Disease Syndrome	Hpfh-Sickle Cell Disease Syndrome
Acquired Methemoglobinemia	Drug-Induced Methemoglobinemia Methemoglobinemia Acquired
Sulfhemoglobinemia
Methemoglobinemia
Congenital Methemoglobinemia	Hereditary Methemoglobinemia Autosomal Recessive Methemoglobinemia Methemoglobinemia Hereditary Hemoglobin M Disease
Beta-Thalassemia	Beta Thalassemia Cooley'S Anemia Mediterranean Anemia Beta Thalassemia Intermedia Erythroblastic Anemia Thalassemia, Hispanic Gamma-Delta-Beta Thalassemia Major Thalassemia Minor Beta-Plus-Thalassemia Thalassemia, Beta Beta Thalassemia Major Beta Thalassemia Minor Thalassemias, Beta- Microcytemia, Beta Type Thalassemia, Beta Type B-THAL Mediterranean Anaemia Beta Thalassaemia Syndrome Mediterranean Disease Beta Thalassaemia Disease
Glucosephosphate Dehydrogenase Deficiency	G6pd Deficiency Glucose-6-Phosphate Dehydrogenase Deficiency Deficiency Of Glucose-6-Phosphate Dehydrogenase Glucose 6 Phosphate Dehydrogenase Deficiency Deficiency Of G-6pd G6pdd
Sickle Cell Disease	Hbs Disease Hemoglobin S Disease Scd Sickle Cell Disorders Sickling Disorder Due To Hemoglobin S Anemia, Sickle Cell Hb-Ss Disease Without Crisis Hbss Without Crisis Sickle-Cell Anaemia Without Crisis Scd - [Sickle Cell Disease] Sca - [Sickle Cell Anaemia] Sickle Cell Disease Nos Sickle Cell Disorder Sickle Cell Syndrome Sickle-Cell Anaemia Nos Sickle-Cell Disorder Nos Haemoglobin S Disease Haemoglobin Ss Disease Hb S Disease Hb Ss Disease Herrick Anaemia Hereditary Haemoglobinopathy Disorder Homozygous For Haemoglobin S Sickle-Cell Haemoglobin Disease Sickling Disorder Due To Haemoglobin S Hb-Ss Disease With Crisis Sickle Cell Crisis Sickle-Cell Disorder With Crisis Sickle-Cell Anaemia With Crisis Hbss With Crisis Hb S Disease With Mention Of Crisis Haemoglobin Ss Disease With Crisis Hb-Ss Disease With Vaso-Occlusive Pain Vaso-Occlusive Crisis
Hemolytic Anemia	Anemia, Hemolytic Anemia Hemolytic Anaemia Due To Other Disorders Of Glutathione Metabolism Chronic Non Spherocytic Anaemia G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia Favism Anaemia Haemolytic Anaemia Due Tog6pd Deficiency Favism Pentose Phosphate Pathway Disorder Anaemia Anaemia Due To Pentose Phosphate Pathway Defect
Alpha-Thalassemia	Alpha Thalassemia Alpha Thalassaemia Alpha Plus Thalassemia Thalassemia, Alpha- Thalassemias, Alpha- A-Thalassemia Α-Thalassemia A-THAL Thalassemia Alpha Thalassaemia Syndrome
Thalassemia	Sickle-Cell Thalassemia With Crisis Sickle-Cell Thalassemia Without Crisis Thalassemia Hb-S Disease With Crisis Thalassemia Hb-S Disease Without Crisis Thalassemias Hereditary Leptocytosis Haemoglobin Thalassaemia Disorder Thalassaemia Syndrome Thalassaemia Nos Thalassemia Variants
Chronic Granulomatous Disease	Cgd Granulomatous Disease, Chronic Autosomal Recessive Chronic Granulomatous Disease X-Linked Chronic Granulomatous Disease Bridges-Good Syndrome Congenital Dysphagocytosis Quie Syndrome Chronic Septic Granulomatosis Chronic Granulomatous Disorder Granulomatous Disease Chronic Granulomatous Disease, Chronic, X-Linked
Iron Deficiency Anemia	Iron-Deficiency Anemia Fe Deficiency Anaemia Ida - [Iron Deficiency Anemia] Fe - [Iron] Deficiency Anemia Nos
Pulmonary Hypertension	Primary Pulmonary Hypertension Hypertension Pulmonary Hypertension, Pulmonary Hypertension, Pulmonary, Primary Idiopathic Pulmonary Hypertension Idiopathic Pulmonary Arterial Hypertension Pulmonary Htn - [Hypertension]
Beta-Thalassemia Intermedia
Hemoglobin C Disease	Hb C Disease Hemoglobin C Hb-C Disease
Thalassemia Minor
Autosomal Dominant Beta Thalassemia	Inclusion Body Beta-Thalassemia
Beta-Thalassemia Major	Cooley'S Anemia Cooley Anemia Mediterranean Anemia
Alpha-Thalassemia Myelodysplasia Syndrome	ATMDS Acquired Hemoglobin H Disease Alpha-Thalassemia Myelodysplasia Syndrome, Somatic Acquired Hbh Disease Alpha-Thalassemia-Myelodysplastic Syndrome Hemoglobin H Disease, Acquired Acquired Alpha-Thalassemia With Myelodysplastic Syndrome Hemoglobin H Disease Acquired Thalassemia, Alpha, Myelodysplasia Syndrome, Somatic
Ghosal Hematodiaphyseal Dysplasia	Ghosal Syndrome Ghosal Hematodiaphyseal Syndrome GHDD Diaphyseal Dysplasia-Anemia Syndrome Ghosal Hematodiaphyseal Dysplasia Syndrome Diaphyseal Dysplasia Associated With Anemia Ghosal Hemato-Diaphyseal Dysplasia Ghosal-Type Hemato-Diaphyseal Dysplasia
Adult Respiratory Distress Syndrome	Acute Respiratory Distress Syndrome Ards Non-Cardiogenic Pulmonary Edema Acute Lung Injury Respiratory Distress Syndrome, Adult Shock Lung Acute Respiratory Distress Respiratory Distress Syndrome Adult Rds Ali Increased-Permeability Pulmonary Edema Stiff Lung Respiratory Distress Syndrome Adult
Sickle Cell Anemia	Hemoglobin Sc Disease Anemia, Sickle Cell Hbsc Disease Sickle Cell-Hemoglobin C Disease Syndrome Hb Ss Disease Sickle Cell Trait Drepanocytosis Haemoglobin Sc Disease Hb Sc Disease Hb-S/Hb-C Disease Hb-Ss Disease Without Crisis Hemoglobin S Disease Without Crisis Sickle Cell Anaemia Sickle-Cell/Hb-C Disease Without Crisis Sickle Cell - Hemoglobin C Disease Hbs Disease Hemoglobin S Disease Sickling Disorder Due To Hemoglobin S SKCA Sickle Cell Disease Sickle Cell-Hemoglobin C Disease Sickle-Cell Disease Carrier Sickle-Cell Heterozygous Disorder Haemoglobin A-S Genotype Hb-S - [Sickle Cell Haemoglobin] Carrier Sickle Cell Haemoglobin Trait As - [Sickle Cell Trait] Hbas - [Sickle Cell Haemoglobin Trait] Sickle-Cell Trait Haemoglobin Disease Haemoglobin Sickle Cell Trait Disorder Heterozygous Sickle Cell Trait Hbas - [Heterozygous Haemoglobin S]
Bilirubin Metabolic Disorder	Hyperbilirubinemia Hereditary Hyperbilirubinemia Hyperbilirubinemia, Hereditary Hyperbilirubinaemia
Hemoglobinopathy	Hemoglobinopathies
Blood Protein Disease	Blood Protein Disorders Blood Protein Disorder
Thrombocytopenia With Beta-Thalassemia, X-Linked	XLTT Thrombocytopenia, Platelet Dysfunction, Hemolysis, And Imbalanced Globin Synthesis Beta-Thalassemia-X-Linked Thrombocytopenia Syndrome Gata1-Related X-Linked Cytopenia X-Linked Thrombocytopenia With Beta-Thalassemia Thrombocytopenia Platelet Dysfunction Hemolysis And Imbalanced Globin Synthesis
Congenital Hemolytic Anemia	Anemia Hemolytic Congenital Anemia, Hemolytic, Congenital Congenital Hemolytic Anaemia Hereditary Hemolytic Anaemia Hereditary Hemolytic Anemia
Neonatal Jaundice	Neonatal Hyperbilirubinemia Neonatal Icterus Jaundice Neonatal Jaundice, Neonatal Hyperbilirubinemia, Neonatal
Deficiency Anemia	Anemia Deficiency Anemias Anaemia
Lung Disease	Lung Diseases Disorder Of Lung Abnormality Of The Lung
Neonatal Anemia	Anemia Neonatal Anemia, Neonatal Anaemia Neonatal Neonatal Anaemia
Hemoglobin E Disease	Hemoglobin E Hb-E Disease
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06031	HBG2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown