NPY2R - neuropeptide Y receptor Y2 Gene

Also Known as NPY2-R

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4887

About NPY2R

Cytogenetic location: 4q32.1 Genomic coordinates (GRCh38): 4:155,173,723-155,217,076 (from NCBI)

This gene has 2 transcripts (splice variants), 248 orthologues and 33 paralogues. Low expression observed in reference dataset.

Summary

Predicted to enable Calcium Channel regulator activity and Neuropeptide Y Receptor activity. Involved in cardiac left ventricle morphogenesis and outflow tract morphogenesis. Located in cilium. Implicated in Huntington's disease; morbid obesity; and obesity. Biomarker of peripheral artery disease and temporal lobe epilepsy. [provided by Alliance of Genome Resources, Apr 2022]

NPY2R Products (3)

mRNA Protein Name
NM_001375470.1 NP_001362399.1 neuropeptide Y receptor type 2
NM_001370180.1 NP_001357109.1 neuropeptide Y receptor type 2
NM_000910.4 NP_000901.1 neuropeptide Y receptor type 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23597562 GOA
Biological Process GO Annotation Evidence References Source
involved in cardiac left ventricle morphogenesis IMP
IMP: Inferred from mutant phenotype
19593212 GOA
involved in outflow tract morphogenesis IMP
IMP: Inferred from mutant phenotype
19593212 GOA
Cellular Component GO Annotation Evidence References Source
located in cilium IDA
IDA: Inferred from direct assay
28154160 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NPY2R Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (67 - 325)

  • 0
  • 100
  • 200
  • 300
  • 381 a.a.
Protein Preferred Names Protein Names

neuropeptide Y receptor type 2

  • NPY-Y2 receptor

NPY2R Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NPY2R P49146 PYY Homo sapiens P10082
SPA
23597562
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Nephronophthisis 4

  • NPHP4

  • Juvenile Nephronophthisis 4

  • Nephronophthisis 4, Juvenile

  • Nephronophthisis, Type 4
Epilepsy

  • Epilepsy Syndrome

  • Epileptic Syndrome

  • Epilepsies

  • Symptomatic Epilepsies

  • Post Traumatic Epilepsy

  • Traumatic Epilepsy

  • Traumatic Epileptic

  • Epilepsy Due To Hippocampal Sclerosis

  • Epilepsy With Ammon'S Horn Sclerosis

  • Epilepsy Due To Cortical Dysplasia

  • Epilepsy Due To Neuronal Migration Disorders
Peripheral Artery Disease

  • Peripheral Arterial Disease

  • Peripheral Arterial Diseases
Temporal Lobe Epilepsy

  • Epilepsy, Temporal Lobe

  • Epilepsy Temporal Lobe
Joubert Syndrome 1

  • Joubert Syndrome

  • Jbts

  • Cerebellooculorenal Syndrome 1

  • JBTS1

  • Joubert-Boltshauser Syndrome

  • Cerebelloparenchymal Disorder Iv

  • Cpd4

  • Cors1

  • Joubert Syndrome And Related Disorders

  • Jsrd

  • Familial Aplasia Of The Vermis

  • Joubert Syndrome Related Disorders

  • Js

  • Cerebellar Vermis Agenesis

  • Cerebelloparenchymal Disorder 4

  • Agenesis Of Cerebellar Vermis

  • Cerebello-Oculo-Renal Syndrome

  • Cors

  • Joubert-Bolthauser Syndrome

  • Cpd Iv

  • Classic Joubert Syndrome

  • Joubert Syndrome Type A

  • Pure Joubert Syndrome

  • Cerebello-Oculo-Renal Syndrome 1

  • Joubert Syndrome-1

  • Joubert Syndrome, Type 1

  • Joubert'S Syndrome
Huntington Disease

  • Huntington'S Disease

  • Huntington Chorea

  • HD

  • Huntington'S Chorea

  • Huntington Chronic Progressive Hereditary Chorea

  • Juvenile Huntington Disease

  • Chronic Progressive Chorea

  • Chronic Progressive Hereditary Chorea

  • Hc - [Huntington Chorea]

  • Hereditary Chorea

  • Progressive Hereditary Chorea
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Obesity , Susceptibility To

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-101986 BIIE-0246 Antagonist 99.10% Unkown
HY-101986A BIIE-0246 hydrochloride Antagonist 99.33% Unkown
HY-RS09514 NPY2R Human Pre-designed siRNA Set A / Unkown
HY-RS09515 Npy2r Mouse Pre-designed siRNA Set A / Unkown
HY-RS09516 NPY2R Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NPY2R MGD MGI:108418
Rattus norvegicus NPY2R RGD RGD:620475
Felis catus NPY2R VGNC VGNC:78538
Macaca mulatta NPY2R VGNC VGNC:100257
Bos taurus NPY2R VGNC VGNC:52806
Others NPY2R NCBI