2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. LXR
  4. GSK-9772

GSK-9772 is a Liver X Receptor (LXR) modulator of the N-phenyl tertiary amine class (NPTAs) with high affinity for LXR β ligand (IC50=30 nM). GSK-9772 has anti-inflammatory activity by binding to LXR, specifically by interacting with the region associated with the transcriptional repression function of the receptor, thereby inhibiting the expression of pro-inflammatory genes. GSK-9772 can be used in the study of inflammatory and neurodegenerative diseases.

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GSK-9772

GSK-9772 화학구조

CAS No. : 928035-84-1

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GSK-9772 Related Antibodies

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제품 설명

GSK-9772 is a Liver X Receptor (LXR) modulator of the N-phenyl tertiary amine class (NPTAs) with high affinity for LXR β ligand (IC50=30 nM). GSK-9772 has anti-inflammatory activity by binding to LXR, specifically by interacting with the region associated with the transcriptional repression function of the receptor, thereby inhibiting the expression of pro-inflammatory genes. GSK-9772 can be used in the study of inflammatory and neurodegenerative diseases[1].

Cellular Effect
Cell Line Type Value Description References
THP-1 IC50
>10 μM
Compound: 5
Transrepressional activity at LXR in human TPA-activated THP1 cells assessed as inhibition of LPS-induced IL6 production incubated for 6 hrs prior to LPS-challenge measured after 18 hrs by ELISA
Transrepressional activity at LXR in human TPA-activated THP1 cells assessed as inhibition of LPS-induced IL6 production incubated for 6 hrs prior to LPS-challenge measured after 18 hrs by ELISA
[PMID: 22873709]
THP-1 IC50
15 nM
Compound: 20, GSK-9772
Antiinflammatory activity against human THP1 cells assessed as inhibition of LPS-stimulated IL6 production after 6 hrs by ELISA
Antiinflammatory activity against human THP1 cells assessed as inhibition of LPS-stimulated IL6 production after 6 hrs by ELISA
[PMID: 18800767]
분자량

490.27

화학식

C20H19Cl2F6NO2
CAS No.
SMILES

OC1=C(Cl)C=C(CN(CCCC)C2=CC=C(C(C(F)(F)F)(O)C(F)(F)F)C=C2)C=C1Cl
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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GSK-9772 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK-9772928035-84-1GSK9772GSK 9772LXRLiver X receptorModulatorsAnti-inflammatory activityTranscriptional repressionNeurodegenerative diseasesInhibitorinhibitorinhibit

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상품명:
GSK-9772
Cat. No.:
HY-14353
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