928035-84-1
Chemical Structure
GSK-9772
- CAS. Nr.: 928035-84-1
- Formula:C20H19Cl2F6NO2
- Molecular Weight:490.27
IUPAC Name: (8S,10S)-10-(((2R,4S,5S,6S)-4-amino-5-(benzyloxy)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione
InChIKey: TYYLMKBOWXDDCT-UHFFFAOYSA-N
SMILES: OC1=C(Cl)C=C(CN(CCCC)C2=CC=C(C(C(F)(F)F)(O)C(F)(F)F)C=C2)C=C1Cl
Biological Activity: GSK-9772 is a Liver X Receptor (LXR) modulator of the N-phenyl tertiary amine class (NPTAs) with high affinity for LXR β ligand (IC50=30 nM). GSK-9772 has anti-inflammatory activity by binding to LXR, specifically by interacting with the region associated with the transcriptional repression function of the receptor, thereby inhibiting the expression of pro-inflammatory genes. GSK-9772 can be used in the study of inflammatory and neurodegenerative diseases[1].
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GSK-9772 | GSK-9772 is a Liver X Receptor (LXR) modulator of the N-phenyl tertiary amine class (NPTAs) with high affinity for LXR β ligand (IC50=30 nM). GSK-9772 has anti-inflammatory activity by binding to LXR, specifically by interacting with the region associated with the transcriptional repression function of the receptor, thereby inhibiting the expression of pro-inflammatory genes. GSK-9772 can be used in the study of inflammatory and neurodegenerative diseases. | |||||||||||||||||||||
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