2. Neuronal Signaling
  3. Amyloid-β
  4. HEPPS

HEPPS (EPPS) is a buffering agent with the useful pH range from 7.3 ~ 8.7. HEPPS reduces Aβ-aggregate-induced memory deficits and rescues cognitive deficits in mice. EPPS is orally active and penetrates the blood-brain barrier.

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HEPPS

HEPPS 화학구조

CAS No. : 16052-06-5

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in Water 해외재고보유
Solid
25 g 해외재고보유
50 g 해외재고보유
> 100 g   견적 받기  

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HEPPS Related Antibodies

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  • Biological Activity

  • 순도&문서

  • References

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제품 설명

HEPPS (EPPS) is a buffering agent with the useful pH range from 7.3 ~ 8.7. HEPPS reduces Aβ-aggregate-induced memory deficits and rescues cognitive deficits in mice. EPPS is orally active and penetrates the blood-brain barrier[1].

In Vitro

HEPPS (0-25 μM, 7 days) binds to amyloid-β aggregates and convert them into monomers, thereby reducing the formation of amyloid-β oligomers and plaques. HEPPS rescues cell damage induced by amyloid-β aggregates[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HEPPS Related Antibodies

Cell Viability Assay[1]

Cell Line: HT-22
Concentration: 25 μM
Incubation Time: 7 days
Result: Improved the cell viability decreased by amyloid-β oligomers.
In Vivo

HEPPS (30 mg/kg/day, po, in drinking water for 3.5 months) improves the cognitive dysfunction in APP/PS1 transgenic mice, and can be used in Alzheimer's disease research[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: APP/PS1 double transgenic mouse model[1]
Dosage: 30 mg/kg/day
Administration: po, in drinking water for 3.5 months
Result: Improved the contextual fear memory deficit, spatial reference memory deficit and spatial working memory deficit of mice.
Reduced Ab oligomer and plaque deposition in the brain of mice.
Reduced glial GABA release in the brain of mice.
분자량

252.33

화학식

C9H20N2O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(CCCN1CCN(CCO)CC1)(O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
용액&용해도
In Vitro: 

H2O : 233.33 mg/mL (924.70 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9631 mL 19.8153 mL 39.6306 mL
5 mM 0.7926 mL 3.9631 mL 7.9261 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (396.31 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
순도&문서

Purity: 99.04%

SDS (393 KB)

COA (243 KB) HNMR (249 KB) LCMS (320 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.9631 mL 19.8153 mL 39.6306 mL 99.0766 mL
5 mM 0.7926 mL 3.9631 mL 7.9261 mL 19.8153 mL
10 mM 0.3963 mL 1.9815 mL 3.9631 mL 9.9077 mL
15 mM 0.2642 mL 1.3210 mL 2.6420 mL 6.6051 mL
20 mM 0.1982 mL 0.9908 mL 1.9815 mL 4.9538 mL
25 mM 0.1585 mL 0.7926 mL 1.5852 mL 3.9631 mL
30 mM 0.1321 mL 0.6605 mL 1.3210 mL 3.3026 mL
40 mM 0.0991 mL 0.4954 mL 0.9908 mL 2.4769 mL
50 mM 0.0793 mL 0.3963 mL 0.7926 mL 1.9815 mL
60 mM 0.0661 mL 0.3303 mL 0.6605 mL 1.6513 mL
80 mM 0.0495 mL 0.2477 mL 0.4954 mL 1.2385 mL
100 mM 0.0396 mL 0.1982 mL 0.3963 mL 0.9908 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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HEPPS Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HEPPS16052-06-5EPPSAmyloid-ββ-amyloid peptideAβAbetaBuffermemory deficitscognitive deficitsorally activeblood-brain barrierInhibitorinhibitorinhibit

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Inquiry Information

상품명:
HEPPS
Cat. No.:
HY-D0873
수량:
MCE Japan Authorized Agent:

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비고

SAFETY DATA SHEET (SDS)

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