Hydroxylapatite (<50 nm)  (Synonyms: Hydroxyapatite (<50 nm))

Hydroxylapatite (Hydroxyapatite) (<50 nm) is a natural form of calcium phosphate and is the main mineral component of bones and teeth. Hydroxylapatite (<50 nm) can stimulate the expression and secretion of collagen in primary human dermal fibroblasts. Hydroxylapatite (<50 nm) has good biocompatibility, bioactivity, and bone conductivity, making it suitable for targeted drug or nucleic acid delivery. Hydroxylapatite (<50 nm) can be used in research on osteoarthritis, gout, and atherosclerosis^[1][2].

Hydroxylapatite is suspended in 0.2 μm filtered purified water, sonicated and vortexed for 5 min and collected by centrifugation at 16,000 g for 1 min. The procedure was repeated five times to wash the Hydroxylapatite particles and a 40 mg/mL stock suspension was prepared in 0.1 M NaCl before administering to cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

502.31

Ca₅HO₁₃P₃

1306-06-5

Solid

White to off-white

O[Ca][Ca][Ca][Ca][Ca]P1(OOO1)=O.O=P2(P3(OOO3)=O)OOO2

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

• [1]. Rakshit M, et al. Hydroxyapatite Particles Induced Modulation of Collagen Expression and Secretion in Primary Human Dermal Fibroblasts. Int J Nanomedicine. 2020 Jul 13;15:4943-4956.  [Content Brief]

  [2]. Yongjia Liu, et al. Hydroxyapatite-Bovine Serum Albumin-Paclitaxel Nanoparticles for Locoregional Treatment of Osteosarcoma. Adv Healthc Mater. 2020 Nov 9;e2000573.  [Content Brief]