Cefamandole: in vitro and clinical pharmacokinetics

Cefamandole has a broader spectrum and greater potency than the Other cephalosporins. It includes Haemophilus influenzae, most strains of Enterobacter, and many strains of indole-positive Proteus and Bacteroides, with a lower minimal inhibitory concentration for Escherichia coli, Klebsiella, etc. Concentrations of drug in the serum after the parenteral injection of cefamandole exceed manyfold the minimal inhibitory concentrations of over 82% of the bacteria studied. Approximately 65 to 85% is excreted in a biologically active form in the urine. This Antibiotic offers advantages of Antibacterial effectiveness and at the same time retains the safety of penicillin G and cephalothin in Animals.