2. Academic Validation
  3. PF1163A and B, new antifungal antibiotics produced by Penicillium sp. II. Physico-chemical properties and structure elucidation

PF1163A and B, new antifungal antibiotics produced by Penicillium sp. II. Physico-chemical properties and structure elucidation

  • J Antibiot (Tokyo). 2000 Jan;53(1):38-44. doi: 10.7164/antibiotics.53.38.
T Sasaki 1,  H Nose,  A Hosoya,  S Yoshida,  M Kawaguchi,  T Watanabe,  T Usui,  Y Ohtsuka,  T Shomura,  S Takano,  K Tatsuta
Affiliations

Affiliation

  • 1 Pharmaceutical Research Center, Meiji Seika, Ltd., Yokohama, Japan.
PMID: 10724006 DOI: 10.7164/antibiotics.53.38
Abstract

The structures of new antifungal Antibiotics, PF1163A and B, were elucidated by spectroscopic analyses of the degradation products and by X-ray crystallography of the de-2-hydroxyethyl derivative of PF1163B. Both Antibiotics consist of a 13-membered macrocyclic structure containing a derivative of N-methyl tyrosine and a hydroxy fatty acid. PF1163A differs from PF 1163B by having an additional hydroxyl group on the side chain.

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