2. Academic Validation
  3. Synthesis and biological activities of NB-506 analogues modified at the glucose group

Synthesis and biological activities of NB-506 analogues modified at the glucose group

  • Bioorg Med Chem Lett. 2000 Mar 6;10(5):419-22. doi: 10.1016/s0960-894x(00)00004-4.
M Ohkubo 1,  T Nishimura,  H Kawamoto,  M Nakano,  T Honma,  T Yoshinari,  H Arakawa,  H Suda,  H Morishima,  S Nishimura
Affiliations

Affiliation

  • 1 Banyu Tsukuba Research Institute, Ibaraki, Japan.
PMID: 10743939 DOI: 10.1016/s0960-894x(00)00004-4
Abstract

A new indolocarbazole compound, NB-506 (1), modified at the glucose group yielded a beta-D-glucopyranoside, J-107,088 (2), which showed potent Anticancer activity. A beta-D-ribofuranoside, J-109,534 (3), was found to be 6 times more potent than J-107,088 at inhibiting Topoisomerase I.

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