2. Academic Validation
  3. 2,4,5-Trisubstituted imidazoles: novel nontoxic modulators of P-glycoprotein mediated multidrug resistance. Part 1

2,4,5-Trisubstituted imidazoles: novel nontoxic modulators of P-glycoprotein mediated multidrug resistance. Part 1

  • Bioorg Med Chem Lett. 2000 Dec 4;10(23):2599-601. doi: 10.1016/s0960-894x(00)00520-5.
S Sarshar 1,  C Zhang,  E J Moran,  S Krane,  J C Rodarte,  K D Benbatoul,  R Dixon,  A M Mjalli
Affiliations

Affiliation

PMID: 11128632 DOI: 10.1016/s0960-894x(00)00520-5
Abstract

N-4,5-Di-(4-dialkylamino)phenyl imidazoles (A) are potent modulators of P-glycoprotein mediated multidrug resistance. This manuscript describes the discovery and lead optimization of this novel class of inhibitors.

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