2. Academic Validation
  3. 2,4,5-Trisubstituted imidazoles: novel nontoxic modulators of P-glycoprotein mediated multidrug resistance. Part 2

2,4,5-Trisubstituted imidazoles: novel nontoxic modulators of P-glycoprotein mediated multidrug resistance. Part 2

  • Bioorg Med Chem Lett. 2000 Dec 4;10(23):2603-5. doi: 10.1016/s0960-894x(00)00521-7.
C Zhang 1,  S Sarshar,  E J Moran,  S Krane,  J C Rodarte,  K D Benbatoul,  R Dixon,  A M Mjalli
Affiliations

Affiliation

  • 1 Ontogen Corporation, Carlsbad, CA 92009, USA.
PMID: 11128633 DOI: 10.1016/s0960-894x(00)00521-7
Abstract

Solution-phase combinatorial chemistry was applied to the optimization and development of clinical candidate OC144-093 (22), a novel and nontoxic modulator of P-glycoprotein mediated multidrug resistance.

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