2. Academic Validation
  3. A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif

A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif

  • Nat Cell Biol. 2000 Dec;2(12):915-21. doi: 10.1038/35046566.
S Larisch 1,  Y Yi,  R Lotan,  H Kerner,  S Eimerl,  W Tony Parks,  Y Gottfried,  S Birkey Reffey,  M P de Caestecker,  D Danielpour,  N Book-Melamed,  R Timberg,  C S Duckett,  R J Lechleider,  H Steller,  J Orly,  S J Kim,  A B Roberts
Affiliations

Affiliation

  • 1 Pathology Department, Rambam Medical Center, Haifa, Israel.
PMID: 11146656 DOI: 10.1038/35046566
Abstract

Here we describe a protein product of the human septin H5/PNUTL2/CDCrel2b gene, which we call ARTS (for apoptosis-related protein in the TGF-beta signalling pathway). ARTS is expressed in many cells and acts to enhance cell death induced by TGF-beta or, to a lesser extent, by other apoptotic agents. Unlike related septin gene products, ARTS is localized to mitochondria and translocates to the nucleus when Apoptosis occurs. Mutation of the P-loop of ARTS abrogates its competence to activate Caspase 3 and to induce Apoptosis. Taken together, these observations expand the functional attributes of septins previously described as having roles in cytokinesis and cellular morphogenesis.

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