2. Academic Validation
  3. Cancer chemopreventive activity of 3,5,6,7,8,3',4'-heptamethoxyflavone from the peel of citrus plants

Cancer chemopreventive activity of 3,5,6,7,8,3',4'-heptamethoxyflavone from the peel of citrus plants

  • Cancer Lett. 2001 Feb 10;163(1):7-9. doi: 10.1016/s0304-3835(00)00691-1.
Y Iwase 1,  Y Takemura,  M Ju-ichi,  M Yano,  C Ito,  H Furukawa,  T Mukainaka,  M Kuchide,  H Tokuda,  H Nishino
Affiliations

Affiliation

  • 1 Faculty of Pharmaceutical Sciences, Mukogawa Women's University, 11-68 Koshien Kyubancho, Nishinomiya, 663-8179, Hyogo, Japan.
PMID: 11163102 DOI: 10.1016/s0304-3835(00)00691-1
Abstract

Nobiletin and 3,5,6,7,8,3',4'-heptamethoxyflavone (HPT), isolated from the peel of Citrus Plants, were examined for the anti-tumor-initiating activity on two-stage carcinogenesis of mouse skin tumors induced by a nitric oxide donor, (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexenamide, as an initiator and 12-O-tetradecanoylphorbol-13-acetate as a promoter. HPT exhibited the remarkable anti-tumor-initiating effect on mouse skin and it suggested the possibility of HPT being a chemopreventive agent against nitric oxide (NO) carcinogenesis.

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