2. Academic Validation
  3. Novel sulfonate analogues of combretastatin A-4: potent antimitotic agents

Novel sulfonate analogues of combretastatin A-4: potent antimitotic agents

  • Bioorg Med Chem Lett. 2001 Apr 9;11(7):871-4. doi: 10.1016/s0960-894x(01)00098-1.
S L Gwaltney 2nd 1,  H M Imade,  K J Barr,  Q Li,  L Gehrke,  R B Credo,  R B Warner,  J Y Lee,  P Kovar,  J Wang,  M A Nukkala,  N A Zielinski,  D Frost,  S C Ng,  H L Sham
Affiliations

Affiliation

  • 1 Cancer Research, Abbott Laboratories, Abbott Park, IL 60064-6101, USA. [email protected]
PMID: 11294380 DOI: 10.1016/s0960-894x(01)00098-1
Abstract

Sulfonate analogues of combretastatin A-4 have been prepared. These compounds compete with colchicine and combretastatin A-4 for the colchicine binding site on tubulin and are potent inhibitors of tubulin polymerization and cell proliferation. Importantly, these compounds also inhibit the proliferation of P-glycoprotein positive (+) Cancer cells, which are resistant to many Other antitumor agents.

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