2. Academic Validation
  3. Thiazole analogues of the NSAID indomethacin as selective COX-2 inhibitors

Thiazole analogues of the NSAID indomethacin as selective COX-2 inhibitors

  • Bioorg Med Chem Lett. 2001 May 21;11(10):1325-8. doi: 10.1016/s0960-894x(01)00212-8.
K W Woods 1,  R W McCroskey,  M R Michaelides,  C K Wada,  K I Hulkower,  R L Bell
Affiliations

Affiliation

PMID: 11392547 DOI: 10.1016/s0960-894x(01)00212-8
Abstract

The carboxyl group of the NSAID indomethacin was replaced with a variety of substituted thiazoles to obtain a series of potent, selective inhibitors of COX-2. Additional substitutions were made at the 1-position and 5-position of the indole of indomethacin.

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