2. Academic Validation
  3. Novel sulfonate derivatives: potent antimitotic agents

Novel sulfonate derivatives: potent antimitotic agents

  • Bioorg Med Chem Lett. 2001 Jul 9;11(13):1671-3. doi: 10.1016/s0960-894x(01)00279-7.
S L Gwaltney 2nd 1,  H M Imade,  Q Li,  L Gehrke,  R B Credo,  R B Warner,  J Y Lee,  P Kovar,  D Frost,  S C Ng,  H L Sham
Affiliations

Affiliation

  • 1 Cancer Research, D47B, Building AP-10, Abbott Laboratories, 60064-6101, Abbott Park, IL, USA
PMID: 11425534 DOI: 10.1016/s0960-894x(01)00279-7
Abstract

The synthesis and biological evaluation of novel sulfonate analogues of E-7010 are reported. Several of the compounds are potent inhibitors of cell proliferation and tubulin polymerization. Importantly, these compounds are also active against P-glycoprotein positive (+) Cancer cells, which are resistant to many Other antitumor agents.

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