2. Academic Validation
  3. Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba

Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba

  • J Nat Prod. 2001 Feb;64(2):204-7. doi: 10.1021/np0004606.
K Suzuki 1,  S Yahara,  K Maehata,  M Uyeda
Affiliations

Affiliation

  • 1 Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-Honmachi, Kumamoto 862-0973, Japan.
PMID: 11430001 DOI: 10.1021/np0004606
Abstract

A novel inhibitor of Topoisomerase I designated as isoaurostatin (1) was isolated from the culture filtrate of Thermomonospora alba strain No. 1520. The structure of 1 was determined to be 6,4'-dihydroxyisoaurone on the basis of spectroscopic (NMR and MS) methods. Compound 1 inhibited the relaxation activity of calf thymus Topoisomerase I in a noncompetitive manner and did not inhibit the relaxation and decatenation of human placenta Topoisomerase II. Compound 1 is an inhibitor belonging to cleavable complex-nonforming type without DNA intercalation.

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