2. Academic Validation
  3. Absolute stereostructures of novel norcadinane- and trinoreudesmane-type sesquiterpenes with nitric oxide production inhibitory activity from Alpinia oxyphylla

Absolute stereostructures of novel norcadinane- and trinoreudesmane-type sesquiterpenes with nitric oxide production inhibitory activity from Alpinia oxyphylla

  • Bioorg Med Chem Lett. 2001 Aug 20;11(16):2217-20. doi: 10.1016/s0960-894x(01)00413-9.
O Muraoka 1,  M Fujimoto,  G Tanabe,  M Kubo,  T Minematsu,  H Matsuda,  T Morikawa,  I Toguchida,  M Yoshikawa
Affiliations

Affiliation

  • 1 School of Pharmaceutical Sciences, Kinki University, 3-4-1 Kowakae, Higashiosaka, 577-8502, Osaka, Japan. [email protected]
PMID: 11514174 DOI: 10.1016/s0960-894x(01)00413-9
Abstract

Novel 14-norcadinane-type Sesquiterpenes, oxyphyllenodiols A and B, and 11,12,13-trinoreudesmane-type Sesquiterpenes, oxyphyllenones A and B, were isolated from the methanolic extract of kernels of Alpinia oxyphylla. The absolute stereostructures of these norsesquiterpenes were determined on the basis of physicochemical and chemical evidence. In addition, oxyphyllenodiol A and oxyphyllenone A were found to inhibit the NO production in lipopolysaccharide-activated macrophages.

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