2. Academic Validation
  3. The alkaloids of Artabotrys uncinatus

The alkaloids of Artabotrys uncinatus

  • J Nat Prod. 2001 Sep;64(9):1157-61. doi: 10.1021/np010036k.
T J Hsieh 1,  F R Chang,  Y C Chia,  C Y Chen,  H C Lin,  H F Chiu,  Y C Wu
Affiliations

Affiliation

  • 1 Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
PMID: 11575948 DOI: 10.1021/np010036k
Abstract

A novel type of alpha,beta-butenolide alkaloid, uncinine (1), two novel oxoaporphines, artabonatine C (2) and artabonatine D (3), a new oxazoloaporphine, artabonatine E (4), and a new 7,7'-bisdehydroaporphine, artabonatine F (5), along with 25 known Alkaloids, were isolated from Artabotrys uncinatus. The structures of 1-5 were determined using NMR and mass spectral data. Atherospermidine and squamolone exhibited cytotoxicity against hepatocarcinoma Cancer cell lines (Hep G(2) and 2,2,15), and the activity of some of the Alkaloids in an antithrombin assay is also discussed.

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