2. Academic Validation
  3. Antiplasmodial activity of naphthoquinones and one anthraquinone from Stereospermum kunthianum

Antiplasmodial activity of naphthoquinones and one anthraquinone from Stereospermum kunthianum

  • Phytochemistry. 2002 May;60(1):39-44. doi: 10.1016/s0031-9422(02)00072-9.
Bernardina Onegi 1,  Carola Kraft,  Inga Köhler,  Marion Freund,  Kristina Jenett-Siems,  Karsten Siems,  Gabriele Beyer,  Matthias F Melzig,  Ulrich Bienzle,  Eckart Eich
Affiliations

Affiliation

  • 1 Department of Pharmacy (Pharmacognosy Unit), Makerere University, Kampala, Uganda.
PMID: 11985850 DOI: 10.1016/s0031-9422(02)00072-9
Abstract

A lipophilic extract of the root bark of Stereospermum kunthianum revealed antiplasmodial activity in vitro. Bioassay-guided fractionation led to the isolation of four novel naphthoquinones (sterekunthals A and B, pyranokunthones A and B) and one novel anthraquinone (anthrakunthone) together with the known naphthoquinone pinnatal. The structures of the novel compounds were determined by comprehensive analyses of their 1D and 2D NMR data. The antiplasmodial activities and toxicity against the endothelial cell line ECV-304 of the isolated compounds have been assessed.

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