Sterekunthal B
Sterekunthal B is a naphthoquinone compound and antimalarial agent. Sterekunthal B can be isolated from plants of the Bignoniaceae family, including the root bark of Stereospermum colais. Sterekunthal B inhibits the growth of Chloroquine (HY-17589A)-sensitive Plasmodium falciparum strain PoW with an IC50 of 23.3 μg/mL. Sterekunthal B also inhibits the growth of Chloroquine-resistant Plasmodium falciparum strain Dd2 with an IC50 of 15.2 μg/mL. Sterekunthal B exhibits non-selective cytotoxicity toward endothelial cells. Sterekunthal B can be used in malaria-related research.
For research use only. We do not sell to patients.
- CAS No.: 475673-78-0
- Formula: C20H18O4
- Molecular Weight:322.35
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Biological Activity
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Plasmodium |
Sterekunthal B inhibits growth of Plasmodium falciparum poW and Dd2 strains with IC50 values of 16-97 μM[1].
Sterekunthal B inhibits the growth of Chloroquine (HY-17589A)-sensitive Plasmodium falciparum PoW strain with an IC50 of 23.3 μg/mL and Chloroquine-resistant Plasmodium falciparum Dd2 strain with an IC50 of 15.2 μg/mL[2].
Sterekunthal B inhibits the proliferation of endothelial ECV-304 cells with an IC50 of 16.0 μg/mL[2].
Sterekunthal B exerts marked non-selective cytotoxicity against human endothelial (ECV-304) cells with an IC50 value of 16 µg/mL[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 475673-78-0
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Molecular Weight 322.35
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Formula C20H18O4
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SMILES
O=C[C@@]1([C@@]23C(C(C4=CC=CC=C4C3=O)=O)=C[C@@]5([H])[C@]1([H])CC[C@]5(O2)C)C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Malerich JP, et al. Biomimetic synthesis of antimalarial naphthoquinones. J Am Chem Soc. 2005 May 4;127(17):6276-83. [Content Brief]
[2]. Onegi B, et al. Antiplasmodial activity of naphthoquinones and one anthraquinone from Stereospermum kunthianum. Phytochemistry. 2002;60(1):39-44. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sterekunthal B Related Classifications
HY-N20619 Related Classifications
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