Biomimetic synthesis of antimalarial naphthoquinones
- J Am Chem Soc. 2005 May 4;127(17):6276-83. doi: 10.1021/ja050092y.
Affiliations
- 1. Department of Chemistry, University of California-Berkeley, Berkeley, California 94720-1460, USA.
PMID: 15853334
DOI: 10.1021/ja050092y
Abstract
The total synthesis of naphthoquinone natural products isolated from the Bignoniaceae plant family is described. Pinnatal, isopinnatal, sterekunthals A and B, pyranokunthones A and B, and anthrakunthone have been prepared along the lines of a biosynthetic proposal involving pericyclic reactions as key steps. The first case of catalysis in oxa 6pi electrocyclizations is reported.
Products
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Cat. No.Product NameDescriptionTargetResearch Area
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target: Parasite