2. Academic Validation
  3. Pyrrolo[2,3-d]pyrimidines containing diverse N-7 substituents as potent inhibitors of Lck

Pyrrolo[2,3-d]pyrimidines containing diverse N-7 substituents as potent inhibitors of Lck

  • Bioorg Med Chem Lett. 2002 Jun 17;12(12):1683-6. doi: 10.1016/s0960-894x(02)00195-6.
David J Calderwood 1,  David N Johnston,  Rainer Munschauer,  Paul Rafferty
Affiliations

Affiliation

  • 1 Abbott Bioresearch Center, 100 Research Drive, Worcester, MA 01605-5314, USA. [email protected]
PMID: 12039590 DOI: 10.1016/s0960-894x(02)00195-6
Abstract

A series of pyrrolo[2,3-d]pyrimidines was synthesized and evaluated as inhibitors of Lck. Lck accommodates a diverse set of substituents at N-7. Altering the substituent at N-7 provided compound 13, an orally available Lck Inhibitor which inhibited TCR mediated IL-2 production after oral dosing.

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