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  3. The synthesis and biological evaluation of a novel series of antimicrobials of the oxazolidinone class

The synthesis and biological evaluation of a novel series of antimicrobials of the oxazolidinone class

  • Bioorg Med Chem Lett. 2002 Aug 19;12(16):2121-3. doi: 10.1016/s0960-894x(02)00352-9.
Richard J Sciotti 1,  Marina Pliushchev,  Paul E Wiedeman,  Darlene Balli,  Robert Flamm,  Angela M Nilius,  Kennan Marsh,  DeAnne Stolarik,  Robert Jolly,  Roger Ulrich,  Stevan W Djuric
Affiliations

Affiliation

  • 1 Abbott Laboratories, Infectious Disease Research, Department 47N, Abbott Park, IL 60064, USA. [email protected]
PMID: 12127518 DOI: 10.1016/s0960-894x(02)00352-9
Abstract

A novel series of antimicrobials of the Oxazolidinone class is disclosed. These compounds are characterized relative to previously described analogues by a 'halostilbene-derived' pharmacophore and demonstrate enhanced antimicrobial activity against key Gram-positive pathogens when compared to Linezolid.

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