2. Academic Validation
  3. Phenolic compounds from Nymphaea odorata

Phenolic compounds from Nymphaea odorata

  • J Nat Prod. 2003 Apr;66(4):548-50. doi: 10.1021/np020442j.
Zhizhen Zhang 1,  Hala N ElSohly,  Xing-Cong Li,  Shabana I Khan,  Sheldon E Broedel Jr,  Robert E Raulli,  Ronald L Cihlar,  Charles Burandt,  Larry A Walker
Affiliations

Affiliation

  • 1 National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, and Department of Pharmacology, School of Pharmacy, University of Mississippi, University, Mississippi 38677, USA.
PMID: 12713413 DOI: 10.1021/np020442j
Abstract

Assay-guided fractionation of the ethanol extract of Nymphaea odorata resulted in the identification of two Lignans, one new (1) and one known (2), together with six known flavonol glycosides (3-8). The structures of 1-8 were established by spectroscopic analysis as nymphaeoside A (1), icariside E(4) (2), kaempferol 3-O-alpha-l-rhamnopyranoside (afzelin, 3), quercetin 3-O-alpha-l-rhamnopyranoside (4), myricetin 3-O-alpha-l-rhamnopyranoside (myricitrin, 5), quercetin 3-O-(6' '-O-acetyl)-beta-d-galactopyranoside (6), myricetin 3-O-beta-d-galactopyranoside (7), and myricetin 3-O-(6' '-O-acetyl)-beta-d-galactopyranoside (8). Compounds 3, 4, and 7 showed marginal inhibitory effect against fatty acid synthase with IC(50) values of 45, 50, and 25 microg/mL, respectively.

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