2. Academic Validation
  3. A novel NO-production-inhibiting triterpene and cytotoxicity of known alkaloids from Euonymus laxiflorus

A novel NO-production-inhibiting triterpene and cytotoxicity of known alkaloids from Euonymus laxiflorus

  • J Nat Prod. 2003 Apr;66(4):554-7. doi: 10.1021/np0203988.
Yao-Haur Kuo 1,  Hui-Chi Huang,  Wen-Fei Chiou,  Li-Shian Shi,  Tian-Shung Wu,  Yang-Chang Wu
Affiliations

Affiliation

  • 1 National Research Institute of Chinese Medicine, No. 155-1, Li-Nong Street, Section 2, Shih-Pai, Taipei, 112, Taiwan, Republic of China. [email protected]
PMID: 12713415 DOI: 10.1021/np0203988
Abstract

A new triterpene, laxifolone A (1), four known sesquiterpene Alkaloids, ebenifoline E-II (2), carigorinine E (3), euojaponine C (4), and emarginatine E (5), and six triterpenoids, 3-hydroxyolean-12-en-22,29-gamma-lactone, 3,11-dioxo-beta-amyrene, 3beta,22alpha-dihydroxyolean-12-en-29-oic acid, 28,29-dihydroxyfriedelan-3-one, 29-hydroxy-3-oxo-D:A-friedooleanan-28-oic acid, and putranjivadione, were isolated from the stems and leaves of Euonymus laxiflorus. Structural elucidations of these compounds were established by spectral analysis. Compound 1 displayed significant nitric oxide (NO) inhibitory effect.

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