2. Academic Validation
  3. Effects of antidepressant drugs and GR 205171, an neurokinin-1 (NK1) receptor antagonist, on the response in the forced swim test and on monoamine extracellular levels in the frontal cortex of the mouse

Effects of antidepressant drugs and GR 205171, an neurokinin-1 (NK1) receptor antagonist, on the response in the forced swim test and on monoamine extracellular levels in the frontal cortex of the mouse

  • Neurosci Lett. 2003 Jul 17;345(2):73-6. doi: 10.1016/s0304-3940(03)00305-7.
Alessandro Zocchi 1,  Giorgia Varnier,  Roberto Arban,  Cristiana Griffante,  Lara Zanetti,  Letizia Bettelini,  Mario Marchi,  Philip A Gerrard,  Mauro Corsi
Affiliations

Affiliation

  • 1 GlaxoSmithKline, Psychiatry Centre of Excellence for Drug Discovery, Via Fleming 4, 37100 Verona, Italy. [email protected]
PMID: 12821174 DOI: 10.1016/s0304-3940(03)00305-7
Abstract

We tested fluoxetine, bupropion and GR 205171, a selective neurokinin-1 receptor antagonist on forced swimming test (FST) response and on levels of monoamines in frontal cortex of CD1 mice by microdialysis techniques. All drugs decreased immobility time. Fluoxetine augmented all monoamines, bupropion enhanced catecholamines, and GR 205171 was totally ineffective. Results suggest that FST response may not be related to levels of monoamines in the mouse frontal cortex.

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