1. GPCR/G Protein
    Neuronal Signaling
  2. Neurokinin Receptor
  3. Vofopitant dihydrochloride

Vofopitant dihydrochloride (Synonyms: GR 205171A)

Cat. No.: HY-12143 Purity: 98.18%
Handling Instructions

Vofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1(NK1) receptor antagonist, inhibits [3H]SP binding to the NK1 receptor with pKi values of 9.5 and 10.6 in rat and human membranes respectively, acts as a potential broad-spectrum anti-emetic agent.

For research use only. We do not sell to patients.

Vofopitant dihydrochloride Chemical Structure

Vofopitant dihydrochloride Chemical Structure

CAS No. : 168266-51-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 389 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Vofopitant dihydrochloride:

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Description

Vofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1(NK1) receptor antagonist, inhibits [3H]SP binding to the NK1 receptor with pKi values of 9.5 and 10.6 in rat and human membranes respectively, acts as a potential broad-spectrum anti-emetic agent[1].

IC50 & Target

pKi: 9.5 (NK1, rat), 10.6 (NK1, human)[1]

Clinical Trial
Molecular Weight

505.36

Formula

C₂₁H₂₅Cl₂F₃N₆O

CAS No.

168266-51-1

SMILES

COC1=C(CN[[email protected]]2CCCN[[email protected]]2C3=CC=CC=C3)C=C(N4N=NN=C4C(F)(F)F)C=C1.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (98.94 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9788 mL 9.8939 mL 19.7879 mL
5 mM 0.3958 mL 1.9788 mL 3.9576 mL
10 mM 0.1979 mL 0.9894 mL 1.9788 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5 mg/mL (9.89 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 5 mg/mL (9.89 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5 mg/mL (9.89 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

VofopitantGR 205171ANeurokinin ReceptorNK receptorInhibitorinhibitorinhibit

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Product Name:
Vofopitant dihydrochloride
Cat. No.:
HY-12143
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