Ipsapirone (Synonyms: TVX Q 7821 free base)

Cat. No.: HY-19686 Purity: 99.87%: FAQs
Data Sheet SDS COA Handling Instructions

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Ipsapirone (TVX Q 7821) is an anxiolytic compound and a 5-HT_1A receptor partial agonist. Ipsapirone (TVX Q 7821) also exhibits 5-HT_1A receptor antagonistic effect, and only at high doses it can also produce an inhibitory effect on 5-HT₂ and the α₁-adrenergic function.

For research use only. We do not sell to patients.

Ipsapirone Chemical Structure

CAS No. : 95847-70-4

Size	Price	Stock	Quantity
5 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 252	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 420	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 695	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Description

In Vivo

Ipsapirone inhibits induced by 8-OH-DPAT and 5-methoxydimethyltryptamine (agonists of 5-HT1A receptors) behavioural effects (flat body posture and forepaw treading) in normal and reserpinized rats^[1].
Ipsapirone (2.5-80 mg/kg), given alone to rats induces a slight flattening of body posture (~ 1 point at the highest dose) and a mild hind limb abduction observed at doses 2.5-80 mg/kg. Ipsapirone given alone at low doses (2.5-10 mg/kg i.p.) does not significantly change the body temperature in rats and mice, but decreased it in both those species at high doses (35 mg/kg i.p.) by ca. 2-2.5℃^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Albino-Swiss mice (18-24 g) and male Wistar rats (160-200 g)^[1].
Dosage:	5 and 10 mg/kg.
Administration:	IP 30 min before 8-OH-DPAT and 5-MeODMT injections.
Result:	Behavioural responses (flat body posture, forepaw treading) to 8-OH-DPAT (5 mg/kg s.c.) in rats were antagonized by Ipsapirone (5 and 10 mg/kg i.p.).

Molecular Weight

401.48

Formula

C₁₉H₂₃N₅O₃S

CAS No.

95847-70-4

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C2C=CC=C1)N(CCCCN3CCN(C4=NC=CC=N4)CC3)S2(=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (62.27 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4908 mL	12.4539 mL	24.9078 mL
5 mM	0.4982 mL	2.4908 mL	4.9816 mL
10 mM	0.2491 mL	1.2454 mL	2.4908 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.87%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (246 KB) LCMS (265 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4908 mL	12.4539 mL	24.9078 mL	62.2696 mL
	5 mM	0.4982 mL	2.4908 mL	4.9816 mL	12.4539 mL
	10 mM	0.2491 mL	1.2454 mL	2.4908 mL	6.2270 mL
	15 mM	0.1661 mL	0.8303 mL	1.6605 mL	4.1513 mL
	20 mM	0.1245 mL	0.6227 mL	1.2454 mL	3.1135 mL
	25 mM	0.0996 mL	0.4982 mL	0.9963 mL	2.4908 mL
	30 mM	0.0830 mL	0.4151 mL	0.8303 mL	2.0757 mL
	40 mM	0.0623 mL	0.3113 mL	0.6227 mL	1.5567 mL
	50 mM	0.0498 mL	0.2491 mL	0.4982 mL	1.2454 mL
	60 mM	0.0415 mL	0.2076 mL	0.4151 mL	1.0378 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ipsapirone95847-70-4TVX Q 7821TVX Q7821TVX Q-7821Inhibitorinhibitorinhibit

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