2. Academic Validation
  3. Melanin biosynthesis inhibitors from the bark of Machilus thunbergii

Melanin biosynthesis inhibitors from the bark of Machilus thunbergii

  • Biol Pharm Bull. 2003 Jul;26(7):1039-41. doi: 10.1248/bpb.26.1039.
Gao Li 1,  Hye Kyung Ju,  Hyuen Wook Chang,  Yurngdong Jahng,  Seung-Ho Lee,  Jong-Keun Son
Affiliations

Affiliation

  • 1 College of Pharmacy, Yeungnam University, Gyongsan, Korea.
PMID: 12843636 DOI: 10.1248/bpb.26.1039
Abstract

The bioassay-guided fractionation of the methylene chloride soluble portion of a methanol extract of Machilus thunbergii bark led to the isolation of four known Lignans, machilin A (1), meso-monomethyl dihydroguaiaretic acid (2), nectandrin A (3) and nectandrin B (4), which exhibited potent inhibitory activity on melanin biosynthesis in cultured B-16 mouse melanoma cells (IC(50): 39.9, 15.1, 19.4 and 37.8 microM, respectively).

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-N12431
    Melanin Synthesis Inhibitor