Machilin A
Machilin A is a lignan isolated from the methanolic extract of Phoebe bark. Machilin A inhibits melanin biosynthesis in B-16 mouse melanoma cells with an IC50 of 39.9 μM.
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- CAS. Nr.: 110269-50-6
- Formel: C20H22O4
- Molecular Weight:326.39
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biologische Aktivität
Beschreibung
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A-375 | IC50 |
235.5 μM
Compound: 2d
|
Cytotoxicity against human A375 cells after 5 days by MTT assay
Cytotoxicity against human A375 cells after 5 days by MTT assay
|
[PMID: 19615898] |
| HepG2 | IC50 |
175.3 μM
Compound: 2d
|
Cytotoxicity against human HepG2 cells after 5 days by MTT assay
Cytotoxicity against human HepG2 cells after 5 days by MTT assay
|
[PMID: 19615898] |
| HT-29 | IC50 |
89.9 μM
Compound: 2d
|
Cytotoxicity against human HT-29 cells after 5 days by MTT assay
Cytotoxicity against human HT-29 cells after 5 days by MTT assay
|
[PMID: 19615898] |
| MCF7 | IC50 |
102.7 μM
Compound: 2d
|
Cytotoxicity against human MCF7 cells after 5 days by MTT assay
Cytotoxicity against human MCF7 cells after 5 days by MTT assay
|
[PMID: 19615898] |
Chemical Information
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CAS. Nr. 110269-50-6
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Molecular Weight 326.39
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Formel C20H22O4
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SMILES
C[C@H](CC1=CC=C(OCO2)C2=C1)[C@@H](C)CC3=CC=C(OCO4)C4=C3
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)