Melanin biosynthesis inhibitors from the bark of Machilus thunbergii

  • Biol Pharm Bull. 2003 Jul;26(7):1039-41. doi: 10.1248/bpb.26.1039.
Gao Li  1 ,  Hye Kyung Ju ,  Hyuen Wook Chang ,  Yurngdong Jahng ,  Seung-Ho Lee ,  Jong-Keun Son
Affiliations
  • 1. College of Pharmacy, Yeungnam University, Gyongsan, Korea.
PMID: 12843636 DOI: 10.1248/bpb.26.1039
Abstract

The bioassay-guided fractionation of the methylene chloride soluble portion of a methanol extract of Machilus thunbergii bark led to the isolation of four known Lignans, machilin A (1), meso-monomethyl dihydroguaiaretic acid (2), nectandrin A (3) and nectandrin B (4), which exhibited potent inhibitory activity on melanin biosynthesis in cultured B-16 mouse melanoma cells (IC(50): 39.9, 15.1, 19.4 and 37.8 microM, respectively).

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