2. Academic Validation
  3. Antimalarial activity of sesquiterpenes from the marine sponge Acanthella klethra

Antimalarial activity of sesquiterpenes from the marine sponge Acanthella klethra

  • J Nat Prod. 1992 Dec;55(12):1787-9. doi: 10.1021/np50090a014.
C K Angerhofer 1,  J M Pezzuto,  G M König,  A D Wright,  O Sticher
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois, Chicago 60612.
PMID: 1294700 DOI: 10.1021/np50090a014
Abstract

Five sesquiterpenoids containing isonitrile or isothiocyanate groups were isolated from the Sponge Acanthella klethra. Compounds 1 and 2 were identified as axisonitrile 3 and the corresponding isothiocyanate derivative, respectively. Compounds 3-5 were found to be eudesmane Sesquiterpenes. None of these compounds was cytotoxic toward cultured KB-3 cells, but varying degrees of activity were observed with cultured Plasmodium falciparum. Compound 1 demonstrated greatest promise as an antimalarial agent.

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