Inhibitory effect of trans-N-p-coumaroyl tryamine from the twigs of Celtis chinensis on the acetylcholinesterase

Arch Pharm Res. 2003 Sep;26(9):735-8. doi: 10.1007/BF02976684.

Dae Keun Kim ¹, Kieseung Lee

Affiliations

Affiliation

1 College of Pharmacy, Woosuk University, Samrye 565-701, Korea. [email protected]

PMID: 14560923 DOI: 10.1007/BF02976684

Abstract

The methanolic extract of the twigs of Celtis chinensis was found to show inhibitory activity on acetylcholinesterase (AChE), an enzyme that plays a role in the metabolic hydrolysis of ACh. Bioassay-guided fractionation of the methanolic extract resulted in the isolation of N-p-coumaroyl tyramine, as an inhibitor on AChE. This compound inhibited AChE activity in a dose-dependent manner, and the IC50 value of trans-N-p-coumaroyl tyramine was 34.5 microg/mL (122 microM).

Products

Cat. No.

Product Name

Description

Target

Research Area
HY-N2230

N-p-trans-Coumaroyltyramine

99.28%, ChE Inhibitor

Cholinesterase (ChE); Parasite; Glycosidase

Neurological Disease; Infection
HY-N2230R

N-p-trans-Coumaroyltyramine (Standard)

ChE Inhibitor

Reference Standards; Cholinesterase (ChE); Parasite; Glycosidase

Neurological Disease; Infection

Name
Email *

	Sorry, but the email address you supplied was invalid.