2. Academic Validation
  3. Alkaloids from Croton flavens L. and their affinities to GABA-receptors

Alkaloids from Croton flavens L. and their affinities to GABA-receptors

  • Nat Prod Res. 2003 Dec;17(6):437-40. doi: 10.1080/1478641031000111516.
Wolfram J Eisenreich 1,  Georg Höfner,  Franz Bracher
Affiliations

Affiliation

  • 1 Department für Pharmazie-Zentrum für Pharmaforschung, Ludwig-Maximilians-Universität, Butenandtstr. 5-13, 81377 München, Germany.
PMID: 14577695 DOI: 10.1080/1478641031000111516
Abstract

Phytochemical investigation of several Plants of Croton flavens L. from Barbados has led to the isolation of the tetrahydroprotoberberine Alkaloids scoulerine and coreximine, as well as the morphinanedienones salutaridine and its racemic form salutarine, sebiferine, norsinoacutine and flavinantine. In a screening for 3H-GABA displacing activity coreximine showed the highest affinity to the GABA(A) receptor.

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