2. Academic Validation
  3. Advances in the hereditary spastic paraplegias

Advances in the hereditary spastic paraplegias

  • Exp Neurol. 2003 Nov;184 Suppl 1:S106-10. doi: 10.1016/j.expneurol.2003.08.005.
John K Fink 1
Affiliations

Affiliation

  • 1 Department of Neurology, University of Michigan and Geriatric Research Education and Clinical Center, Ann Arbor Veterans Affairs Medical Center, Ann Arbor, MI, USA. [email protected]
PMID: 14597333 DOI: 10.1016/j.expneurol.2003.08.005
Abstract

This review summarizes advances in understanding the genetics of the hereditary spastic paraplegias (HSPs), a diverse group of inherited disorders in which the primary symptom is insidiously progressive difficulty walking due to lower extremity spastic weakness. Twenty HSP loci and nine HSP genes have been discovered. This progress has yielded new insights into the diverse molecular pathogenesis that underlies these clinically similar disorders.

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