2. Academic Validation
  3. Cytotoxicity and antimicrobial activity of goniothalamin isolated from Bryonopsis laciniosa

Cytotoxicity and antimicrobial activity of goniothalamin isolated from Bryonopsis laciniosa

  • Phytother Res. 2003 Dec;17(10):1155-7. doi: 10.1002/ptr.1303.
M Ashik Mosaddik 1,  M Ekramul Haque
Affiliations

Affiliation

  • 1 Centre for Phytochemistry, Southern Cross University, Lismore, NSW 2480, Australia. [email protected]
PMID: 14669248 DOI: 10.1002/ptr.1303
Abstract

The cytotoxicity and antimicrobial activity of goniothalamin isolated from Bryonopsis laciniosa was investigated. Goniothalamin showed potent cytotoxicity with LC50 values (5.03 microg/mL) comparable with the reference standard agent, gallic acid. It also showed weak Antibacterial and significant Antifungal activity against a wide range of gram positive and gram negative bacteria and fungi. The Antibacterial (minimum inhibitory concentration) effect against Bacillus cereus and Shigella shiga was found to be 64 microg/mL.

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