2. Academic Validation
  3. Synthesis and biological activity of new quinoxaline antibiotics of echinomycin analogues

Synthesis and biological activity of new quinoxaline antibiotics of echinomycin analogues

  • Bioorg Med Chem Lett. 2004 Jan 19;14(2):541-4. doi: 10.1016/j.bmcl.2003.09.086.
Yun Bong Kim 1,  Yong Hae Kim,  Ju Youn Park,  Soo Kie Kim
Affiliations

Affiliation

  • 1 Center for Molecular Design and Synthesis, Department of Chemistry, Korea Advanced Institute of Science and Technology, 305-701, Taejon, South Korea.
PMID: 14698199 DOI: 10.1016/j.bmcl.2003.09.086
Abstract

Novel quinoxaline Antibiotics having the methylenedithioether bridge as an analogue of echinomycin have been synthesized by insertion of methylene moiety between -S-S- bond. The compound 1a shows remarkable cytotoxicities against human tumor various cell lines, and is active VRE (vancomycin-resistant enterococci) within MIC range 0.5-8 microg/mL. According to the eukaryotic or prokaryotic data, 1a might be a first analogue to replace echinomycin.

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