2. Academic Validation
  3. Antihypertensive effects of Undaria pinnatifida (wakame) peptide on blood pressure in spontaneously hypertensive rats

Antihypertensive effects of Undaria pinnatifida (wakame) peptide on blood pressure in spontaneously hypertensive rats

  • J Nutr Biochem. 2004 May;15(5):267-72. doi: 10.1016/j.jnutbio.2003.11.004.
Kunio Suetsuna 1,  Keisei Maekawa,  Jiun-Rong Chen
Affiliations

Affiliation

  • 1 Department of Food Science and Technology, National Fisheries University, Yamaguchi 759-6595, Japan. [email protected]
PMID: 15135150 DOI: 10.1016/j.jnutbio.2003.11.004
Abstract

We examined the angiotensin I-converting Enzyme (ACE) inhibitory activity and antihypertensive effect of the hot water extract of wakame, Undaria pinnatifida. Ten dipeptides were isolated from the extract by several steps of chromatography, and their amino acid sequences were Tyr-His, Lys-Trp, Lys-Tyr, Lys-Phe, Phe-Tyr, Val-Trp, Val-Phe, Ile-Tyr, Ile-Trp, and Val-Tyr. Both single administration and repeated oral administration of synthetic Tyr-His, Lys-Tyr, Phe-Tyr, and Ile-Tyr significantly decreased blood pressure in spontaneously hypertensive rats.

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