2. Academic Validation
  3. New isoprenylated flavones, artochamins A--E, and cytotoxic principles from Artocarpus chama

New isoprenylated flavones, artochamins A--E, and cytotoxic principles from Artocarpus chama

  • J Nat Prod. 2004 May;67(5):757-61. doi: 10.1021/np030467y.
Yong-Hong Wang 1,  Ai-Jun Hou,  Lei Chen,  Dao-Feng Chen,  Han-Dong Sun,  Qin-Shi Zhao,  Kenneth F Bastow,  Yuka Nakanish,  Xi-Hong Wang,  Kuo-Hsiung Lee
Affiliations

Affiliation

  • 1 Department of Pharmacognosy, School of Pharmacy, Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, People's Republic of China.
PMID: 15165133 DOI: 10.1021/np030467y
Abstract

Five new isoprenylated Flavones, artochamins A-E (1-5), together with eight known Flavones (6-13), were isolated from the roots of Artocarpus chama. All structures were elucidated by spectroscopic methods. Artonin E (12) showed strong cytotoxicity against 1A9 (ovarian), significant activity against MCF-7 (breast adenocarcinoma), and moderate activity against HCT-8 (ileocecal) and MDA-MB-231 (breast adenocarcinoma) tumor cell lines. Artochamin C (3) was more potent against MCF-7, 1A9, HCT-8, and SK-MEL-2 (melanoma) than A549 (lung carcinoma), KB (epidermoid carcinoma of the nasopharynx), and its drug-resistant (KB-VIN) variant. Artocarpin (6) displayed weak but relatively broad inhibitory effects compared with 3 and 12.

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