2. Academic Validation
  3. 6-Arylamino-7-chloro-quinazoline-5,8-diones as novel cytotoxic and DNA topoisomerase inhibitory agents

6-Arylamino-7-chloro-quinazoline-5,8-diones as novel cytotoxic and DNA topoisomerase inhibitory agents

  • Bioorg Med Chem Lett. 2004 Jul 5;14(13):3385-8. doi: 10.1016/j.bmcl.2004.04.094.
Hyen Joo Park 1,  Young-Shin Kim,  Jin Sung Kim,  Eun-Jin Lee,  You-Jin Yi,  Hye Jin Hwang,  Myung-Eun Suh,  Chung-Kyu Ryu,  Sang Kook Lee
Affiliations

Affiliation

  • 1 College of Pharmacy, Ewha Womans University, 11-1 Daehyun-dong, Seodaemun-ku, Seoul 120-750, South Korea.
PMID: 15177438 DOI: 10.1016/j.bmcl.2004.04.094
Abstract

A series of 6-arylamino-7-chloro-quinazoline-5,8-diones were prepared and evaluated for their in vitro cytotoxicity in cultured human Cancer cell lines A549 (lung Cancer), Col2 (colon Cancer), and SNU-638 (stomach Cancer). The preliminary structure-activity relationship has been described for providing further development of potent antitumor agents. To further investigate the cytotoxic mechanism, the effects of test compounds on DNA Topoisomerase I and II activities have been assessed.

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