2. Academic Validation
  3. Isolation and structure of gustastatin from the Brazilian nut tree Gustavia hexapetala

Isolation and structure of gustastatin from the Brazilian nut tree Gustavia hexapetala

  • J Nat Prod. 2004 Jun;67(6):983-5. doi: 10.1021/np030509i.
George R Pettit 1,  Qingwen Zhang,  Véronique Pinilla,  Delbert L Herald,  Dennis L Doubek,  James A Duke
Affiliations

Affiliation

  • 1 Cancer Research Institute, Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287-2404, USA. [email protected]
PMID: 15217278 DOI: 10.1021/np030509i
Abstract

A bioassay-guided investigation of Gustavia hexapetala led to the isolation of a new Cancer cell growth inhibitor designated gustastatin (1) and four previously known Cancer cell growth inhibitors that included betulinic acid (2). The structures were assigned on the basis of analyses of HRMS combined with 1D and 2D NMR data. The structure of portentol (5) was confirmed by an X-ray crystal structure determination.

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