2. Academic Validation
  3. 5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP

5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP

  • Bioorg Med Chem Lett. 2004 Oct 18;14(20):5067-70. doi: 10.1016/j.bmcl.2004.07.069.
Richard Sulsky 1,  Jeffrey A Robl,  Scott A Biller,  Thomas W Harrity,  John Wetterau,  Fergal Connolly,  Kern Jolibois,  Lori Kunselman
Affiliations

Affiliation

  • 1 Department of Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA. [email protected]
PMID: 15380200 DOI: 10.1016/j.bmcl.2004.07.069
Abstract

5-Carboxamido-1,3,2-dioxaphosphorinanes have been identified as potent inhibitors of microsomal triglyceride-transfer protein. The 1,3,2-dioxaphosphorine functionality acted as a neutral and stable replacement for piperidine and piperidine N-oxide.

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