2. Academic Validation
  3. Human neutrophil alpha-defensin 4 inhibits HIV-1 infection in vitro

Human neutrophil alpha-defensin 4 inhibits HIV-1 infection in vitro

  • FEBS Lett. 2005 Jan 3;579(1):162-6. doi: 10.1016/j.febslet.2004.11.062.
Zhibin Wu 1,  Fiorenza Cocchi,  David Gentles,  Bryan Ericksen,  Jacek Lubkowski,  Anthony Devico,  Robert I Lehrer,  Wuyuan Lu
Affiliations

Affiliation

  • 1 Institute of Human Virology, University of Maryland Biotechnology Institute, 725 West Lombard Street, Baltimore, MD 21201, USA.
PMID: 15620707 DOI: 10.1016/j.febslet.2004.11.062
Abstract

Human neutrophil alpha-defensin 4 (HNP4) is more effective than HNP1-3 in protecting human peripheral blood mononuclear cells from Infection by both X4 and R5 HIV-1 strains. HNP4 binds to both CD4 and gp120 approximately two orders of magnitude weaker than does HNP1, and is less effectively sequestered by glycosylated serum proteins than HNP1. These results suggest that the HIV-1 inhibition by HNP4 stems at least partially from a unique and lectin-independent property of HNP4 with CD4 and/or gp120. Our finding identifies an anti-HIV-1 property of HNP4 and may have implications in the development of new Antiviral agents for AIDS therapy.

Figures