2. Academic Validation
  3. Biomimetic synthesis of antimalarial naphthoquinones

Biomimetic synthesis of antimalarial naphthoquinones

  • J Am Chem Soc. 2005 May 4;127(17):6276-83. doi: 10.1021/ja050092y.
Jeremiah P Malerich 1,  Thomas J Maimone,  Gregory I Elliott,  Dirk Trauner
Affiliations

Affiliation

  • 1 Department of Chemistry, University of California-Berkeley, Berkeley, California 94720-1460, USA.
PMID: 15853334 DOI: 10.1021/ja050092y
Abstract

The total synthesis of naphthoquinone natural products isolated from the Bignoniaceae plant family is described. Pinnatal, isopinnatal, sterekunthals A and B, pyranokunthones A and B, and anthrakunthone have been prepared along the lines of a biosynthetic proposal involving pericyclic reactions as key steps. The first case of catalysis in oxa 6pi electrocyclizations is reported.

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