2. Academic Validation
  3. Chemokine-like factor 1 is a functional ligand for CC chemokine receptor 4 (CCR4)

Chemokine-like factor 1 is a functional ligand for CC chemokine receptor 4 (CCR4)

  • Life Sci. 2006 Jan 2;78(6):614-21. doi: 10.1016/j.lfs.2005.05.070.
Ying Wang 1,  Yingmei Zhang,  Xue Yang,  Wenling Han,  Yanan Liu,  Qianmei Xu,  Rui Zhao,  Chunhui Di,  Quansheng Song,  Dalong Ma
Affiliations

Affiliation

  • 1 Center for Human Disease Genomics, Peking University, Beijing, PR China.
PMID: 16137713 DOI: 10.1016/j.lfs.2005.05.070
Abstract

Chemokine-like factor 1 (CKLF1) exhibits chemotactic effects on leukocytes. Its amino acid sequence shares similarity with those of TARC/CCL17 and MDC/CCL22, the cognate ligands for CCR4. The chemotactic effects of CKLF1 for CCR4-transfected cells could be desensitized by TARC/CCL17 and markedly inhibited by PTX. CKLF1 induced a calcium flux in CCR4-transfected cells and fully desensitized a subsequent response to TARC/CCL17, and TARC/CCL17 could partly desensitize the response to CKLF1. CKLF1 caused significant receptor internalization in pCCR4-EGFP transfected cells. Taken together, CKLF1 is a novel functional ligand for CCR4.

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