2. Academic Validation
  3. Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection

Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection

  • Bioorg Med Chem Lett. 2006 Jan 1;16(1):118-22. doi: 10.1016/j.bmcl.2005.09.039.
Andrew Burchat 1,  David W Borhani,  David J Calderwood,  Gavin C Hirst,  Biqin Li,  Robert F Stachlewitz
Affiliations

Affiliation

  • 1 Abbott Bioresearch Center, 100 Research Drive, Worcester, MA 01605-5314, USA.
PMID: 16216497 DOI: 10.1016/j.bmcl.2005.09.039
Abstract

We describe the identification, SAR, and pharmacology of the src-family selective Lck Inhibitor A-770041 that prolongs the survival of major histocompatibility mismatched allografts in models of solid organ transplant rejection for greater than 65 days.

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